Endocrine Abstracts

The Case: We are presenting a 51-year-old Caucasian lady with known type 1 diabetes who was diagnosed with Autoimmune Addison’s Disease (AAD) during investigation of persistent hyponatremia. She was admitted with DKA back in November 2022 that was believed to be due to gastroenteritis. Usually, her diabetes control has been reasonable over the years with no severe chronic complications or diabetes-related hospital admissions. In the hospital, she suffered from ongoing hyp...

Background: Confident recognition of atypical genitalia of the newborn and early referral to specialist centres allows for the smooth and successful management of DSD patients. Midwives conduct the majority of newborn infant physical exam (NIPE) yet may not be confident in recognising DSD and talking to families affected.Aim: To develop an e-learning module for examining newborn genitalia, recognising the significance of differences in genital appearance...

Introduction: We hypothesised that children with type 1 diabetes would have more hyperglycaemia following a British as compared to a European breakfast.Methods: Children were asked to take a continental breakfast and a typical British breakfast cereal on separate days. Pre breakfast glucometer readings were documented and then regular readings until lunchtime. The meals were prescribed by a dietitian; they were approximately carbohydrate matched but of d...

Introduction: Children and young people with Turner Syndrome have regular follow up with a paediatric multidisciplinary team to monitor growth, puberty and cardiac comorbidities. As these young women transition to adult care, they need ongoing follow-up for surveillance of potential morbidity and reproductive issues. Following publication of the International Turner Syndrome Consensus Group guidelines on transitional care, a review of current clinical practice in our tertiary ...

Background: Raised blood pressure (BP) in adolescents with type 1 Diabetes Mellitus (T1DM) has been associated with adverse cardiovascular outcomes independently of raised HbA1c. It is therefore of critical importance that these patients are identified early and appropriate treatment instigated. Of concerns, studies have recognised suboptimal management of hypertension in most of these young people, allowing them to succumb to complications of diabetes with hypertension in the...

Introduction: Turners’ syndrome (TS) affects one in 2500 live births. Multiple comorbidities affect TS patients and recommendations for long-term management advocate annual review with a ‘checklist’ approach. This audit of current practice of a specialist TS clinic aims to identify gaps in patients’ management.Methods: A checklist of recommendations for health screening based on the National Turner’s Syndrome Guidelines was devel...

Insulin resistance (IR) has been proven to increase the risks for cardiovascular complications in type 2 diabetes mellitus. Recently, IR has also been shown to play a bigger role in the natural history of type 1 diabetes mellitus (T1DM) disease process than is commonly recognized. The objectives of this study are to determine the prevalence of IR among Filipino adults with T1DM and to describe the clinical features of T1DM with IR.This cross-sectional an...

Context: Pendrin is a transmembrane protein located at the apical end of the thyrocyte where it mediates the efflux of iodide through the thyroid follicular cell. Recently, pendrin was described as a significant antibody target in Japanese patients with Graves’ disease or autoimmune hypothyroidism using an immunoblotting assay. However, a subsequent study failed to verify this in autoimmune thyroid disease patients of Tunisian origin.Objective: The ...

GH deficiency is recognised as a complication of adult traumatic brain injury (TBI) but there are conflicting data in children possibly due to the influences such as age at TBI, trauma mechanism but also by timing, method and criteria of hormonal evaluation.Objectives: To assess the long-term impact of TBI on the GH–IGF1 axis following TBI in childhood.Patients: Longitudinal study of 28 participants with a history of moderate/...

Prostate cancer development and progression depend on androgen signaling through the androgen receptor (AR). Recent evidence indicates the continued presence of intratumoral dihydrotestosterone (DHT) during androgen deprivation therapy drives prostate cancer recurrence through the activation of AR. There are ongoing efforts to identify drugs that target AR and enzymes that catalyze the synthesis of testosterone and DHT. Temporary remediation of prostate cancer by surgical or m...